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Spotlight on CDER Science

Summaries of research conducted by CDER staff

Bispecific Antibodies: An Area of Research and Clinical Applications

Bispecific antibodies (BsAbs) have two distinct binding domains that can bind to two antigens or two epitopes (an antigen part) of the same antigen simultaneously. Over the past two decades, BsAb development has been revolutionized due to genetic engineering approaches that enable a wide variety of molecular structures that offer different advantages and disadvantages.

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